Laurent Brochard Selected Research

Positive-Pressure Respiration (Positive End-Expiratory Pressure)

2/2022	Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients.
1/2022	Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis.
1/2021	Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome.
1/2021	Role of Positive End-Expiratory Pressure and Regional Transpulmonary Pressure in Asymmetrical Lung Injury.
1/2020	Potential for Lung Recruitment Estimated by the Recruitment-to-Inflation Ratio in Acute Respiratory Distress Syndrome. A Clinical Trial.
1/2020	Patient self-inflicted lung injury and positive end-expiratory pressure for safe spontaneous breathing.
1/2020	Respiratory physiology of COVID-19-induced respiratory failure compared to ARDS of other etiologies.
2/2017	Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.
9/2016	Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives.
1/2016	Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS.

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Laurent Brochard Research Topics

Disease

49	Respiratory Insufficiency (Respiratory Failure) 11/2021 - 08/2002
48	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2022 - 07/2002
30	Critical Illness (Critically Ill) 01/2022 - 03/2003
16	Acute Lung Injury 01/2016 - 07/2002
15	Lung Injury 01/2022 - 09/2002
13	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 04/2003
13	Hypoxia (Hypoxemia) 07/2021 - 06/2009
11	Infections 01/2022 - 07/2002
8	COVID-19 01/2022 - 01/2020
8	Pulmonary Edema 01/2018 - 09/2002
7	Pneumonia (Pneumonitis) 01/2022 - 01/2003
7	Shock 10/2020 - 11/2003
7	Patient-Ventilator Asynchrony 09/2016 - 10/2006
7	Acute Kidney Injury (Acute Renal Failure) 10/2013 - 04/2004
6	Ventilator-Induced Lung Injury 01/2022 - 02/2013
6	Sepsis (Septicemia) 01/2022 - 03/2005
6	Hypercapnia 02/2017 - 02/2008
5	Cross Infection (Nosocomial Infection) 04/2016 - 02/2002
4	Dyspnea (Shortness of Breath) 01/2022 - 11/2005
4	Delirium 01/2020 - 02/2010
4	Body Weight (Weight, Body) 01/2018 - 04/2002
3	Inflammation (Inflammations) 01/2022 - 03/2006
3	Fatigue 01/2022 - 11/2011
3	Muscle Weakness 01/2017 - 10/2009
3	Neoplasms (Cancer) 12/2016 - 09/2002
3	Human Influenza (Influenza) 05/2016 - 05/2011
3	Lung Diseases (Lung Disease) 02/2016 - 08/2010
3	Renal Insufficiency (Renal Failure) 12/2012 - 12/2003
3	Fibrosis (Cirrhosis) 12/2004 - 05/2003
2	Septic Shock (Toxic Shock Syndrome) 01/2022 - 05/2012
2	Respiratory Acidosis 01/2022 - 01/2017
2	Pulmonary Atelectasis 12/2020 - 12/2006
2	Edema (Dropsy) 01/2020 - 09/2002
2	Acidosis 01/2020 - 02/2017
2	Out-of-Hospital Cardiac Arrest 01/2018 - 06/2006
2	Ventilator-Associated Pneumonia 07/2014 - 11/2005
2	Paralysis (Palsy) 05/2013 - 09/2006
2	Obstructive Lung Diseases (Obstructive Lung Disease) 10/2012 - 08/2010
2	Pulmonary Hypertension 09/2010 - 03/2008
2	Sickle Cell Anemia (Hemoglobin S Disease) 08/2010 - 12/2003
2	Acute Chest Syndrome 08/2010 - 03/2008
2	Pain (Aches) 08/2010 - 12/2003
2	Bacterial Pneumonia 08/2004 - 09/2002
2	Neutropenia 01/2003 - 09/2002
1	Pulmonary Embolism 01/2022
1	Primary Graft Dysfunction 09/2021
1	Atrophy 10/2020
1	Hyperoxia 03/2019

Drug/Important Bio-Agent (IBA)

27	Oxygen (Dioxygen)IBA 01/2022 - 01/2002
7	Surface-Active Agents (Surfactants)IBA 01/2022 - 03/2006
5	Colloids (Colloid)IBA 09/2012 - 12/2004
5	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 05/2003 - 09/2002
4	Lidocaine (Xylocaine)FDA LinkGeneric 01/2022 - 09/2002
4	Carbon DioxideIBA 01/2022 - 02/2006
4	Biomarkers (Surrogate Marker)IBA 03/2019 - 03/2006
4	GasesIBA 01/2010 - 11/2005
3	Interleukin-6 (Interleukin 6)IBA 01/2022 - 01/2018
3	Hypnotics and Sedatives (Sedatives)IBA 01/2020 - 11/2015
3	HeliumIBA 01/2017 - 01/2010
3	Anti-Bacterial Agents (Antibiotics)IBA 05/2016 - 01/2010
3	Pharmaceutical PreparationsIBA 02/2016 - 01/2010
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2006 - 09/2002
2	Adrenal Cortex Hormones (Corticosteroids)IBA 10/2020 - 05/2011
2	Hydrocortisone (Cortisol)FDA LinkGeneric 10/2020 - 11/2012
2	Proteins (Proteins, Gene)FDA Link 03/2019 - 09/2002
2	Pancreatic Elastase (Elastase)IBA 01/2018 - 08/2004
2	AerosolsIBA 02/2016 - 10/2011
2	NitrogenIBA 06/2015 - 01/2011
2	SteroidsIBA 03/2014 - 05/2011
2	Bleomycin (Blenoxane)FDA LinkGeneric 08/2004 - 05/2003
2	EndotoxinsIBA 08/2004 - 01/2003
2	Peroxidase (Myeloperoxidase)IBA 05/2003 - 09/2002
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2003 - 09/2002
2	Interleukin-1beta (Interleukin 1 beta)IBA 01/2003 - 09/2002
1	fibrin fragment D (D-dimer)IBA 01/2022
1	Biological ProductsIBA 01/2022
1	Neuromuscular Blocking AgentsIBA 07/2021
1	AntioxidantsIBA 03/2019
1	Superoxide DismutaseIBA 03/2019
1	Interleukin-17 (Interleukin 17)IBA 03/2019
1	HMGB1 Protein (HMG1)IBA 03/2019

Therapy/Procedure

61	Artificial Respiration (Mechanical Ventilation) 01/2022 - 01/2002
38	Noninvasive Ventilation 11/2020 - 08/2002
26	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 02/2022 - 04/2002
23	Therapeutics 01/2022 - 09/2002
18	Mechanical Ventilators (Ventilator) 11/2021 - 04/2004
13	Critical Care (Surgical Intensive Care) 01/2022 - 03/2005
10	Extracorporeal Membrane Oxygenation 01/2022 - 02/2013
8	Cannula 01/2022 - 06/2015
7	Length of Stay 01/2022 - 04/2004
4	Humidifiers 01/2021 - 11/2005
3	Transplantation 09/2021 - 08/2011
3	Resuscitation 12/2013 - 12/2008
2	Deep Sedation 01/2022 - 09/2006
2	Continuous Positive Airway Pressure 03/2021 - 11/2005
2	Tracheostomy 01/2020 - 05/2003
2	Interactive Ventilatory Support 03/2016 - 11/2011
2	Catheters 11/2006 - 11/2003
2	Drug Therapy (Chemotherapy) 01/2003 - 09/2002
1	Patient Readmission 12/2020